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This information will help to constrain neural network topologies [ 66 68] and to reveal how anatomical motifs contribute to the computation of Drosophila action timing. Our dynamical models inform a long-standing debate about the relative influence of neural fluctuations on animal behavior [ 12, 24]. Unlike in peripheral sensory circuits, fluctuations in central circuits may largely arise from deterministic signals that occur naturally within highly interconnected networks of neurons.
Intriguingly, our models predict that fluctuating activity in central action selection circuits may act in a stochastic resonance-like manner [ 5] to linearize the relationship between sensory drive and behavioral output. This suggests a potentially beneficial role for neural fluctuations in increasing the dynamic range of sensory responses in complex environments.
Drosophila Canton-S strains were used in odor-impulse ( Fig 1) and basal locomotion experiments ( Fig 3A). Drosophila melanogaster Genetic Reference Panel (DGRP) [ 49] strains were used in odor-impulse experiments (Figs 2 4C and 4E).